Ingrid Holm

Ingrid Holm, MD, MPH

Attending Physician, Division of Endocrinology; Attending Physician, Division of Genetics and Genomics
Professor of Pediatrics, Harvard Medical School
Member, HMS Center for Bioethics
BCH Division of Genetics and Genomics, 3 Blackfan Circle, Boston, MA 02115

Ingrid A. Holm, MD, MPH is Professor of Pediatrics at Harvard Medical School, faculty in the Division of Genetics and Genomics at Boston Children's Hospital, and teaching faculty at the HMS Center for Bioethics. She is a medical geneticist by training, and she has a certificate in Pediatric Bioethics.

Dr. Holm's primary area of research is the Ethical, Legal, and Social Implications (ELSI) of genomics. She is co-PI of an NIH-funded grant to look at the implementation of genome sequencing as screening in a diverse cohort of healthy infants (BabySeq2). She is co-PI of an NHGRI grant to providing ethical guidance for the development of individualized genomic medicines as rare as n-of-1. She is a co-investigator in the NHGRI-funded Electronic Medical Records and Genomics (eMERGE) Network; a co-investigator at the Harvard Undiagnosed Diseases Network (UDN) site; and Associate Director of Robert's Program in Sudden Unexpected Death in Pediatrics (SUDP), which takes an innovative approach to SUDP as a group of rare genetic diseases. Dr. Holm is Chair of BCH IRB and a member of the NIH-funded All of Us (Precision Medicine Initiative) Research Program IRB.

Publications View
The role of sodium channels in sudden unexpected death in pediatrics.
Authors: Authors: Rochtus AM, Goldstein RD, Holm IA, Brownstein CA, Pérez-Palma E, Haynes R, Lal D, Poduri AH.
Mol Genet Genomic Med
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Further delineation of the clinical spectrum of KAT6B disorders and allelic series of pathogenic variants.
Authors: Authors: Zhang LX, Lemire G, Gonzaga-Jauregui C, Molidperee S, Galaz-Montoya C, Liu DS, Verloes A, Shillington AG, Izumi K, Ritter AL, Keena B, Zackai E, Li D, Bhoj E, Tarpinian JM, Bedoukian E, Kukolich MK, Innes AM, Ediae GU, Sawyer SL, Nair KM, Soumya PC, Subbaraman KR, Probst FJ, Bassetti JA, Sutton RV, Gibbs RA, Brown C, Boone PM, Holm IA, Tartaglia M, Ferrero GB, Niceta M, Dentici ML, Radio FC, Keren B, Wells CF, Coubes C, Laquerrière A, Aziza J, Dubucs C, Nampoothiri S, Mowat D, Patel MS, Bracho A, Cammarata-Scalisi F, Gezdirici A, Fernandez-Jaen A, Hauser N, Zarate YA, Bosanko KA, Dieterich K, Carey JC, Chong JX, Nickerson DA, Bamshad MJ, Lee BH, Yang XJ, Lupski JR, Campeau PM.
Genet Med
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Children's rare disease cohorts: an integrative research and clinical genomics initiative.
Authors: Authors: Rockowitz S, LeCompte N, Carmack M, Quitadamo A, Wang L, Park M, Knight D, Sexton E, Smith L, Sheidley B, Field M, Holm IA, Brownstein CA, Agrawal PB, Kornetsky S, Poduri A, Snapper SB, Beggs AH, Yu TW, Williams DA, Sliz P.
NPJ Genom Med
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Development of osteoarthritis in patients with degenerative meniscal tears treated with exercise therapy or surgery: a randomized controlled trial.
Authors: Authors: Berg B, Roos EM, Englund M, Kise NJ, Tiulpin A, Saarakkala S, Engebretsen L, Eftang CN, Holm I, Risberg MA.
Osteoarthritis Cartilage
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Understanding the Return of Genomic Sequencing Results Process: Content Review of Participant Summary Letters in the eMERGE Research Network.
Authors: Authors: Lynch JA, Sharp RR, Aufox SA, Bland ST, Blout C, Bowen DJ, Buchanan AH, Halverson C, Harr M, Hebbring SJ, Henrikson N, Hoell C, Holm IA, Jarvik G, Kullo IJ, Kochan DC, Larson EB, Lazzeri A, Leppig KA, Madden J, Marasa M, Myers MF, Peterson J, Prows CA, Kulchak Rahm A, Ralston J, Milo Rasouly H, Scrol A, Smith ME, Sturm A, Stuttgen K, Wiesner G, Williams MS, Wynn J, Williams JL.
J Pers Med
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Returning Results in the Genomic Era: Initial Experiences of the eMERGE Network.
Authors: Authors: Wiesner GL, Kulchak Rahm A, Appelbaum P, Aufox S, Bland ST, Blout CL, Christensen KD, Chung WK, Clayton EW, Green RC, Harr MH, Henrikson N, Hoell C, Holm IA, Jarvik GP, Kullo IJ, Lammers PE, Larson EB, Lindor NM, Marasa M, F Myers M, Peterson JF, Prows CA, Ralston JD, Milo Rasouly H, Sharp RR, Smith ME, Van Driest SL, Williams JL, Williams MS, Wynn J, Leppig KA.
J Pers Med
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Concurrent prenatal drinking and smoking increases risk for SIDS: Safe Passage Study report.
Authors: Authors: Elliott AJ, Kinney HC, Haynes RL, Dempers JD, Wright C, Fifer WP, Angal J, Boyd TK, Burd L, Burger E, Folkerth RD, Groenewald C, Hankins G, Hereld D, Hoffman HJ, Holm IA, Myers MM, Nelsen LL, Odendaal HJ, Petersen J, Randall BB, Roberts DJ, Robinson F, Schubert P, Sens MA, Sullivan LM, Tripp T, Van Eerden P, Wadee S, Willinger M, Zaharie D, Dukes KA.
EClinicalMedicine
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Children's rare disease cohorts: an integrative research and clinical genomics initiative.
Authors: Authors: Rockowitz S, LeCompte N, Carmack M, Quitadamo A, Wang L, Park M, Knight D, Sexton E, Smith L, Sheidley B, Field M, Holm IA, Brownstein CA, Agrawal PB, Kornetsky S, Poduri A, Snapper SB, Beggs AH, Yu TW, Williams DA, Sliz P.
NPJ Genom Med
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FDA oversight of NSIGHT genomic research: the need for an integrated systems approach to regulation.
Authors: Authors: Milko LV, Chen F, Chan K, Brower AM, Agrawal PB, Beggs AH, Berg JS, Brenner SE, Holm IA, Koenig BA, Parad RB, Powell CM, Kingsmore SF.
NPJ Genom Med
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IgG Fc glycosylation as an axis of humoral immunity in childhood.
Authors: Authors: Cheng HD, Tirosh I, de Haan N, Stöckmann H, Adamczyk B, McManus CA, O'Flaherty R, Greville G, Saldova R, Bonilla FA, Notarangelo LD, Driessen GJ, Holm IA, Rudd PM, Wuhrer M, Ackerman ME, Nigrovic PA.
J Allergy Clin Immunol
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