Ingrid Holm

Ingrid Holm, MD, MPH

Attending Physician, Division of Endocrinology; Attending Physician, Division of Genetics and Genomics
Professor of Pediatrics, Harvard Medical School
Member, HMS Center for Bioethics
BCH Division of Genetics and Genomics, 3 Blackfan Circle, Boston, MA 02115

Ingrid A. Holm, MD, MPH is Professor of Pediatrics at Harvard Medical School, faculty in the Division of Genetics and Genomics at Boston Children's Hospital, and teaching faculty at the HMS Center for Bioethics. She is a medical geneticist by training, and she has a certificate in Pediatric Bioethics.

Dr. Holm's primary area of research is the Ethical, Legal, and Social Implications (ELSI) of genomics. She is co-PI of an NIH-funded grant to look at the implementation of genome sequencing as screening in a diverse cohort of healthy infants (BabySeq2). She is co-PI of an NHGRI grant to providing ethical guidance for the development of individualized genomic medicines as rare as n-of-1. She is a co-investigator in the NHGRI-funded Electronic Medical Records and Genomics (eMERGE) Network; a co-investigator at the Harvard Undiagnosed Diseases Network (UDN) site; and Associate Director of Robert's Program in Sudden Unexpected Death in Pediatrics (SUDP), which takes an innovative approach to SUDP as a group of rare genetic diseases. Dr. Holm is Chair of BCH IRB and a member of the NIH-funded All of Us (Precision Medicine Initiative) Research Program IRB.

Publications View
Rethinking the "open future" argument against predictive genetic testing of children.
Authors: Authors: Garrett JR, Lantos JD, Biesecker LG, Childerhose JE, Chung WK, Holm IA, Koenig BA, McEwen JE, Wilfond BS, Brothers K.
Genet Med
View full abstract on Pubmed
Response to Knoppers et al.
Authors: Authors: David KL, Best RG, Brenman LM, Bush L, Deignan J, Flannery D, Hoffman JD, Holm I, Miller DT, O'Leary J, Pyeritz RE.
Genet Med
View full abstract on Pubmed
Patient re-contact after revision of genomic test results: points to consider-a statement of the American College of Medical Genetics and Genomics (ACMG).
Authors: Authors: David KL, Best RG, Brenman LM, Bush L, Deignan JL, Flannery D, Hoffman JD, Holm I, Miller DT, O'Leary J, Pyeritz RE.
Genet Med
View full abstract on Pubmed
Enrichment sampling for a multi-site patient survey using electronic health records and census data.
Authors: Authors: Mercaldo ND, Brothers KB, Carrell DS, Clayton EW, Connolly JJ, Holm IA, Horowitz CR, Jarvik GP, Kitchner TE, Li R, McCarty CA, McCormick JB, McManus VD, Myers MF, Pankratz JJ, Shrubsole MJ, Smith ME, Stallings SC, Williams JL, Schildcrout JS.
J Am Med Inform Assoc
View full abstract on Pubmed
Parental interest in genomic sequencing of newborns: enrollment experience from the BabySeq Project.
Authors: Authors: Genetti CA, Schwartz TS, Robinson JO, VanNoy GE, Petersen D, Pereira S, Fayer S, Peoples HA, Agrawal PB, Betting WN, Holm IA, McGuire AL, Waisbren SE, Yu TW, Green RC, Beggs AH, Parad RB.
Genet Med
View full abstract on Pubmed
Expanding the phenotypic spectrum associated with OPHN1 variants.
Authors: Authors: Schwartz TS, Wojcik MH, Pelletier RC, Edward HL, Picker JD, Holm IA, Towne MC, Beggs AH, Agrawal PB.
Eur J Med Genet
View full abstract on Pubmed
Physicians' perspectives on receiving unsolicited genomic results.
Authors: Authors: Pet DB, Holm IA, Williams JL, Myers MF, Novak LL, Brothers KB, Wiesner GL, Clayton EW.
Genet Med
View full abstract on Pubmed
Interpretation of Genomic Sequencing Results in Healthy and Ill Newborns: Results from the BabySeq Project.
Authors: Authors: Ceyhan-Birsoy O, Murry JB, Machini K, Lebo MS, Yu TW, Fayer S, Genetti CA, Schwartz TS, Agrawal PB, Parad RB, Holm IA, McGuire AL, Green RC, Rehm HL, Beggs AH.
Am J Hum Genet
View full abstract on Pubmed
Returning a Genomic Result for an Adult-Onset Condition to the Parents of a Newborn: Insights From the BabySeq Project.
Authors: Authors: Holm IA, McGuire A, Pereira S, Rehm H, Green RC, Beggs AH.
Pediatrics
View full abstract on Pubmed
FDA oversight of NSIGHT genomic research: the need for an integrated systems approach to regulation.
Authors: Authors: Milko LV, Chen F, Chan K, Brower AM, Agrawal PB, Beggs AH, Berg JS, Brenner SE, Holm IA, Koenig BA, Parad RB, Powell CM, Kingsmore SF.
NPJ Genom Med
View full abstract on Pubmed