Ingrid Holm

Ingrid Holm, MD, MPH

Attending Physician, Division of Endocrinology; Attending Physician, Division of Genetics and Genomics
Professor of Pediatrics, Harvard Medical School
Member, HMS Center for Bioethics
BCH Division of Genetics and Genomics, 3 Blackfan Circle, Boston, MA 02115
617-919-2338

Ingrid A. Holm, MD, MPH is Professor of Pediatrics at Harvard Medical School, faculty in the Division of Genetics and Genomics at Boston Children's Hospital, and teaching faculty at the HMS Center for Bioethics. She is a medical geneticist by training, and she has a certificate in Pediatric Bioethics.

Dr. Holm's primary area of research is the Ethical, Legal, and Social Implications (ELSI) of genomics. She is co-PI of an NIH-funded grant to look at the implementation of genome sequencing as screening in a diverse cohort of healthy infants (BabySeq2). She is co-PI of an NHGRI grant to providing ethical guidance for the development of individualized genomic medicines as rare as n-of-1. She is a co-investigator in the NHGRI-funded Electronic Medical Records and Genomics (eMERGE) Network; a co-investigator at the Harvard Undiagnosed Diseases Network (UDN) site; and Associate Director of Robert's Program in Sudden Unexpected Death in Pediatrics (SUDP), which takes an innovative approach to SUDP as a group of rare genetic diseases. Dr. Holm is Chair of BCH IRB and a member of the NIH-funded All of Us (Precision Medicine Initiative) Research Program IRB.

Publications View
Prospective, multi-site study of healthcare utilization after actionable monogenic findings from clinical sequencing.
Authors: Authors: Linder JE, Tao R, Chung WK, Kiryluk K, Liu C, Weng C, Connolly JJ, Hakonarson H, Harr M, Leppig KA, Jarvik GP, Veenstra DL, Aufox S, Chisholm RL, Gordon AS, Hoell C, Rasmussen-Torvik LJ, Smith ME, Holm IA, Miller EM, Prows CA, Elskeally O, Kullo IJ, Lee C, Jose S, Manolio TA, Rowley R, Padi-Adjirackor NA, Wilmayani NK, City B, Wei WQ, Wiesner GL, Rahm AK, Williams JL, Williams MS, Peterson JF.
Am J Hum Genet
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NBSTRN Tools to Advance Newborn Screening Research and Support Newborn Screening Stakeholders.
Authors: Authors: Chan K, Hu Z, Bush LW, Cope H, Holm IA, Kingsmore SF, Wilhelm K, Scharfe C, Brower A.
Int J Neonatal Screen
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Participant-guided development of bilingual genomic educational infographics for Electronic Medical Records and Genomics Phase IV study.
Authors: Authors: Casillan A, Florido ME, Galarza-Cornejo J, Bakken S, Lynch JA, Chung WK, Mittendorf KF, Berner ES, Connolly JJ, Weng C, Holm IA, Khan A, Kiryluk K, Limdi NA, Petukhova L, Sabatello M, Wynn J.
J Am Med Inform Assoc
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Education and electronic medical records and genomics network, challenges, and lessons learned from a large-scale clinical trial using polygenic risk scores.
Authors: Authors: Connolly JJ, Berner ES, Smith M, Levy S, Terek S, Harr M, Karavite D, Suckiel S, Holm IA, Dufendach K, Nelson C, Khan A, Chisholm RL, Allworth A, Wei WQ, Bland HT, Clayton EW, Soper ER, Linder JE, Limdi NA, Miller A, Nigbur S, Bangash H, Hamed M, Sherafati A, Lewis ACF, Perez E, Orlando LA, Rakhra-Burris TK, Al-Dulaimi M, Cifric S, Scherr CL, Wynn J, Hakonarson H, Sabatello M.
Genet Med
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Advancing Understanding of Inequities in Rare Disease Genomics.
Authors: Authors: Serrano JG, O'Leary M, VanNoy GE, Mangilog BE, Holm IA, Fraiman YS, Rehm HL, O'Donnell-Luria A, Wojcik MH.
Clin Ther
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Studying the impact of translational genomic research: Lessons from eMERGE.
Authors: Authors: Clayton EW, Smith ME, Anderson KC, Chung WK, Connolly JJ, Fullerton SM, McGowan ML, Peterson JF, Prows CA, Sabatello M, Holm IA.
Am J Hum Genet
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Actionability of unanticipated monogenic disease risks in newborn genomic screening: Findings from the BabySeq Project.
Authors: Authors: Green RC, Shah N, Genetti CA, Yu T, Zettler B, Uveges MK, Ceyhan-Birsoy O, Lebo MS, Pereira S, Agrawal PB, Parad RB, McGuire AL, Christensen KD, Schwartz TS, Rehm HL, Holm IA, Beggs AH.
Am J Hum Genet
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Returning Individual Research Results from Digital Phenotyping in Psychiatry.
Authors: Authors: Shen FX, Baum ML, Martinez-Martin N, Miner AS, Abraham M, Brownstein CA, Cortez N, Evans BJ, Germine LT, Glahn DC, Grady C, Holm IA, Hurley EA, Kimble S, Lázaro-Muñoz G, Leary K, Marks M, Monette PJ, Onnela JP, O'Rourke PP, Rauch SL, Shachar C, Sen S, Vahia I, Vassy JL, Baker JT, Bierer BE, Silverman BC.
Am J Bioeth
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Perspectives of Rare Disease Experts on Newborn Genome Sequencing.
Authors: Authors: Gold NB, Adelson SM, Shah N, Williams S, Bick SL, Zoltick ES, Gold JI, Strong A, Ganetzky R, Roberts AE, Walker M, Holtz AM, Sankaran VG, Delmonte O, Tan W, Holm IA, Thiagarajah JR, Kamihara J, Comander J, Place E, Wiggs J, Green RC.
JAMA Netw Open
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Returning integrated genomic risk and clinical recommendations: The eMERGE study.
Authors: Authors: Linder JE, Allworth A, Bland HT, Caraballo PJ, Chisholm RL, Clayton EW, Crosslin DR, Dikilitas O, DiVietro A, Esplin ED, Forman S, Freimuth RR, Gordon AS, Green R, Harden MV, Holm IA, Jarvik GP, Karlson EW, Labrecque S, Lennon NJ, Limdi NA, Mittendorf KF, Murphy SN, Orlando L, Prows CA, Rasmussen LV, Rasmussen-Torvik L, Rowley R, Sawicki KT, Schmidlen T, Terek S, Veenstra D, Velez Edwards DR, Absher D, Abul-Husn NS, Alsip J, Bangash H, Beasley M, Below JE, Berner ES, Booth J, Chung WK, Cimino JJ, Connolly J, Davis P, Devine B, Fullerton SM, Guiducci C, Habrat ML, Hain H, Hakonarson H, Harr M, Haverfield E, Hernandez V, Hoell C, Horike-Pyne M, Hripcsak G, Irvin MR, Kachulis C, Karavite D, Kenny EE, Khan A, Kiryluk K, Korf B, Kottyan L, Kullo IJ, Larkin K, Liu C, Malolepsza E, Manolio TA, May T, McNally EM, Mentch F, Miller A, Mooney SD, Murali P, Mutai B, Muthu N, Namjou B, Perez EF, Puckelwartz MJ, Rakhra-Burris T, Roden DM, Rosenthal EA, Saadatagah S, Sabatello M, Schaid DJ, Schultz B, Seabolt L, Shaibi GQ, Sharp RR, Shirts B, Smith ME, Smoller JW, Sterling R, Suckiel SA, Thayer J, Tiwari HK, Trinidad SB, Walunas T, Wei WQ, Wells QS, Weng C, Wiesner GL, Wiley K, Peterson JF.
Genet Med
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